&nbsp Home Documentation &nbsp News &nbsp What's SEVENS &nbsp Statistics Previous Ver. &nbsp 1.72(2014/12/05) &nbsp 1.60(2009/06/23) &nbsp 1.50(2008/07/17) &nbsp 1.40(2006/08/15) &nbsp 1.30(2005/05/17) Links &nbsp AIST &nbsp GPCRDB &nbsp NCBI &nbsp UCSC &nbsp Ensembl &nbsp Broad Institute &nbsp BCM &nbsp dictyBase &nbsp IRGSP &nbsp Swiss-Prot &nbsp PROSITE &nbsp Pfam		Welcome to SEVENS database Information SEVENS summarizes GPCR (G-protein coupled receptor) genes that are identified with high accuracy from 68 eukaryote genomes, by a pipeline integrating such software as a gene finder, a sequence alignment tool, a motif and domain assignment tool, and a transmembrane helix predictor. This treats a larger data space (than that in currently available other databases), which should include not only the expressed sequences but also the newly identified sequences that cannot be detected by in vivo experiments, although they definitely exist on the genome sequence and are just waiting for the opportunity to express their functions. SEVENS can provides the infrastructure of general information of "GPCR universe" for comparative genomics. Our information Makiko Suwa, Yukiteru Ono, Minoru Sugihara, Tatsuya Nishizawa, Toshiyuki Sato, Ikuo Okouchi, Toshitaka Kumagai, Masanori Arita, Wataru Fujibuchi, Kiyoshi Asai and Yutaka Akiyama Computational Biology Research Center (CBRC),National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koutou-ku, Tokyo 135-0064, JAPAN. Shinichi Matsumoto, Shuichi Tsutsumi and Hiroyuki Aburatani Genome Science Division, RCAST, Univ. Tokyo, 4-6-1 Komaba,Meguro-ku, Tokyo 153-8904, JAPAN. Reference Automatic gene collection system for genome-scale overview of G-protein coupled receptors in eukaryotes. Ono Y, Fujibuchi W, Suwa M. Gene.364,63-73(2005). Computational overview of GPCR gene universe to support reverse chemical genomics study. Suwa M, Ono Y. Methods Mol Biol.577,41-54(2009). Database Genome GPCR No. Large Families Human (Homo sapiens) 1265 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chemokines and chemotactic factors receptors gate.io gate.iogate.iogate.io 1203 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Family T2R receptors (taste receptors) Gorilla (Gorilla gorilla) 867 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chemokines and chemotactic factors receptors Orangutan (Pongo abelii) 1211 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Pheromone receptors Baboon (Papio hamadryas) 1066 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chemokines and chemotactic factors receptors Rhesus (Rhesus macaque) 1000 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Family T2R receptors (taste receptors) Lemur (Microcebus murinus) 1204 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Tarsier (Tarsius syrichta) 1034 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Marmoset (Callithrix jacchus) 1010 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Galago (Ottolemur garnetti) 1068 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Tree shrew (Tupaia belangeri) 2196 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Hedgehog (Erinaceus europaeu) 1316 Odorant/olfactory and gustatory receptors Pheromone receptors Family T2R receptors (taste receptors) Common shrew (Sorex araneus) 1571 Odorant/olfactory and gustatory receptors Pheromone receptors Family T2R receptors (taste receptors) Tenrec (Echinops telfairi) 1232 Odorant/olfactory and gustatory receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Family 2 (B) receptors Guinea pig (Cavia porcellus) 1466 Odorant/olfactory and gustatory receptors Pheromone receptors Family T2R receptors (taste receptors) Rat (Rattus norvegicus) 2334 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Mouse (Mus musculus) 2320 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Squirrel (Spermophilus tridecemlineatus) 2252 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Hyrax (Procavia capensis) 1306 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Pheromone receptors Bat (Pteropus vampyrus) 1243 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Trace amine receptors Bat (Myotis lucifugus) 830 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chemokines and chemotactic factors receptors Horse (Equus caballus) 2596 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Dog (Canis familiaris) 1438 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chemokines and chemotactic factors receptors Cat (Felis catus) 931 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Cow (Bos taurus) 2606 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Alpaca (Vicugna pacos) 1222 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Dolphin (Tursiops truncatus) 507 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Rabbit (Oryctolagus cuniculus) 1367 Odorant/olfactory and gustatory receptors Pheromone receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Rabbit (Ochotona princeps) 1069 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Elephant (Loxodonta africana) 3470 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Armadillo (Dasypus novemcinctus) 2191 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Sloth (Choloepus hoffmanni) 2343 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Opossum (Monodelphis domestica) 2083 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Wallaby (Macropus eugenii) 2050 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Platypus (Ornithorhynchus anatinus) 1777 Pheromone receptors Odorant/olfactory and gustatory receptors Family 2 (B) receptors Chicken (Gallus gallus) 683 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Adenosine and adenine nucleotide receptors Zebra finch (Taeniopygia guttata) 736 Odorant/olfactory and gustatory receptors Family 2 (B) receptors Adenosine and adenine nucleotide receptors Lizard (Anolis carolinensis) 686 Odorant/olfactory and gustatory receptors Pheromone receptors Family 2 (B) receptors Western clawed frog (Xenopus tropicalis) 2418 Odorant/olfactory and gustatory receptors Pheromone receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Medaka (Oryzias latipes) 744 Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Odorant/olfactory and gustatory receptors Stickleback (Gasterosteus aculeatus) 771 Odorant/olfactory and gustatory receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Family 2 (B) receptors Pufferfish (Tetraodon nigroviridis) 618 Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Odorant/olfactory and gustatory receptors Fugu (Fugu rubripes) 655 Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Family 2 (B) receptors Odorant/olfactory and gustatory receptors Zebrafish (Danio rerio) 1050 Trace amine receptors Odorant/olfactory and gustatory receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Lamprey (Petromyzon marinus) 281 Odorant/olfactory and gustatory receptors Trace amine receptors Adenosine and adenine nucleotide receptors Sea squirt (Ciona intestinalis) 112 Family 2 (B) receptors Family fz/smo receptors Acetylcholine (muscarinic) receptors Fruit fly (Drosophila melanogaster) 251 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila simulans) 247 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila yakuba) 264 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila pseudoobscura) 246 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila ananassae) 249 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila erecta) 248 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila grimshawi) 251 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila mojavensis) 225 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila persimilis) 231 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila sechellia) 255 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila virilis) 227 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Fruit fly (Drosophila willistoni) 260 Insect chemosensory receptors Family 2 (B) receptors Family 3 (C) receptors (metabotropic glutamate and calcium receptors) Mosquito (Anopheles gambiae) 236 Insect chemosensory receptors Family 2 (B) receptors Opsins Nematode (Caenorhabditis elegans) 1308 Nematode chemoreceptors Serpentine receptor-like proteins Sre proteins Nematode (Caenorhabditis remanei) 1101 Nematode chemoreceptors Serpentine receptor-like proteins Sre proteins Nematode (Caenorhabditis brenneri) 1250 Nematode chemoreceptors Serpentine receptor-like proteins Sre proteins Nematode (Caenorhabditis briggsae) 904 Nematode chemoreceptors Serpentine receptor-like proteins Sre proteins Nematode (Caenorhabditis japonica) 453 Nematode chemoreceptors Serpentine receptor-like proteins Dopamine receptors Mouse-ear cress (Arabidopsis thaliana) 19 Plant MLO receptors Rice (Oryza sativa) 15 Plant MLO receptors gate io gate iogate iogate io 30 Family 5 receptors (slime mold receptors) Budding yeast (Saccharomyces cerevisiae) 6 Archaeal/bacterial/fungal opsin family Family 4 receptors (fungal receptors) Acknowledgement We are pleased to acknowledge the use of the BLAST package from NCBI, the SOSUI from Dr. T. Hirokawa, the ALN from Dr. O. Gotoh, the HMMER from Dr. A. Bateman. This work was supported by KAKENHI (208059) (Grant-in-Aid for Publication of Scientific Research Results) of Japan Society for the Promotion of Science (JSPS). Comments or questions to m-suwa@aist.go.jp Recent Revise on 2018/1/29. Copyright © Aoyama Gakuin University. All Rights Reserved.